Study warns popular NAD-boosting supplements may help pancreatic cancer cells resist chemo

CLEVELAND - Popular anti-aging supplements that raise NAD+ levels may help pancreatic cancer cells survive chemotherapy, according to a Case Western Reserve University study summarized by Fox News.

Researchers tested vitamin B3 derivatives used to make NAD+, including nicotinamide mononucleotide (NMN), nicotinamide riboside (NR) and nicotinamide (NAM). In cell cultures and animal models, the compounds shielded pancreatic cancer cells against oxaliplatin, 5-fluorouracil and gemcitabine, doses that would normally kill more of the tumor cells.

NAD+ helps healthy cells make energy and repair damage. The study found cancer cells can use the same boost to repair chemo injury and keep growing. Lead author Jordan Winter, a professor at Case Western Reserve School of Medicine, called the finding a warning for people in active cancer treatment and urged oncology teams to ask patients about over-the-counter supplements.

Pancreatic cancer remains one of the deadliest common cancers, with a five-year survival rate around 13%, according to American Cancer Society figures cited in coverage of the paper, which appeared in Cancer Letters.

The researchers said the supplements are not shown to be dangerous for healthy people using them for general wellness. The concern is concentrated in patients on chemo. The work was not a human clinical trial, covered only pancreatic cancer, and measured short-term lab responses. Effects on other cancers or long-term patient outcomes are not proven.

Winter advised patients in treatment to talk with their oncologist before taking NAD boosters. Pharmacies and cancer clinics can add a simple supplement question to intake forms. For adults 50 and older who buy NMN or NR for energy or aging, the practical rule is simple: if you have cancer, clear it with the doctor first.